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A focus on degradation of ribosomal RNAs by the TRAMP/exosome RNA surveillance machinery (RRNA SURVEILLANCE)
Start date: Oct 1, 2007, End date: Sep 30, 2009,
Nuclear surveillance and degradation of aberrant RNA requires the TRAMP complex, which promotes exosome-mediated degradation in the nucleus by adding poly (A) tails to aberrant RNAs. Interestingly, a mutant yeast strain defective in nuclear export of 60S preribosomes (sda1-2) accumulates ribosomal proteins, the TRAMP complex and the nuclear exosome in a punctate nucleolar structure, suggesting tha ...
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