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Characterisation of the structure of the early oligomeric aggregates on the amyloidogenic pathway of lysozyme (AMYLBODY)
Start date: Oct 1, 2007, End date: Sep 30, 2009,
Aberrant folding and aggregation of soluble proteins into amyloid-like deposits has been associated to more than 20 known human disorders, including Alzheimer's disease, spongiform encephalopathies and type II diabetes. Recent research has indicated that the early oligomers present prior to amyloid fibril formation represent the most dangerous species to the cell and that their specific conformati ...
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