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Tricyclic Peptides for the Development of Therapeutics (CyPepUTICS)

Start date: Jun 1, 2014, End date: May 31, 2016,

Peptide macrocycles can bind with high affinity and selectivity to protein targets and are an attractive class of molecules for the development of therapeutics. Recently, a phage display-based strategy was developed that allowed to generate potent bicyclic peptide antagonists (Heinis, C., et al., Nat. Chem. Biol., 2009). While bicyclic peptides with nanomolar affinities to a range of protein targe ...
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