6 European Projects Found
Searched on 125080 European Projects
FINISHED
The COMET (Core Outcome Measures in Effectiveness Trials) Initiative (COMET)
Start date: Oct 1, 2012, End date: Dec 31, 2014,
"Clinical trialists often struggle when trying to choose the outcomes to measure which would be of most use to the patients, practitioners and policy makers who will use their research to help them make decisions. These difficulties are passed on to those producing and reading systematic reviews, many of whom have experienced the frustration of finding that the original researchers either did not ...
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11
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Modelling human ageing: developing and interrogating an integrated model of ageing to identify causal relationships between hormonal changes and gene expression changes (INTEGRAGEING)
Start date: Nov 15, 2012, End date: Nov 14, 2014,
"Ageing has a profound impact on human society and modern medicine, yet it remains a major puzzle of biology. Both hormonal and gene expression changes have been implicated as causal mechanisms of ageing. It is not clear, however, which molecular or physiological changes are more important drivers of the process of ageing or how they influence each other. This project aims to develop and interroga ...
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1
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Integrated signalling networks in muscle stem cells: cell fate regulation by heparan sulfates (SATCELLOMICS)
Start date: Nov 1, 2012, End date: Oct 31, 2014,
"Skeletal muscle stem cells (satellite cells - SCs), are undifferentiated progenitors that reside mitotically quiescent in a specialized anatomical niche between the plasma membrane of muscle fibres and the basal lamina: the SC niche. SCs can remain quiescent for long periods of time, but in response to injury become rapidly activated, proliferate and then undergo terminal differentiation. The mol ...
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1
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Modelling and simulation environment for systems medicine\n(Chronic obstructive pulmonary disease -COPD- as a use case) (SYNERGY-COPD)
Start date: Feb 1, 2011, End date: Apr 30, 2014,
Synergy will develop a simulation environment and a decision-support system aiming at enabling deployment of systems medicine. The three core elements are a knowledge base (KB), an inference engine (IE), and a graphical visualisation environment (GVE). The project focuses on patients with chronic obstructive pulmonary disease (COPD).The KB will include five well established physiological models ad ...
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9
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Functional Characterisation of the Plant Nuclear Pore Complex (PLANTNPC)
Start date: Mar 1, 2012, End date: Feb 28, 2014,
"The primary objective of this proposal is to enable Dr Parry to conduct research that will establish him as a world leader in study of the Plant Nuclear Pore Complex (NPC). This will be achieved using a multidisciplinary approach to develop molecular tools and novel uses of technology to understand the critical roles of the NPC in plant cell biology. The initial findings of this work will importa ...
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1
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Identification and functional characterization of genes associated with cellular biomarkers of longevity (LONGENES)
Start date: Oct 1, 2009, End date: Sep 30, 2013,
"Cellular resistance to stress, including resistance to oxidative stress thought to play a role in ageing and cancer, is a major biomarker of longevity. Indeed, increased cellular stress resistance may mediate the life-extending effects of longevity genes in mice. Therefore, there is a great interest in identifying additional genes involved in susceptibility to stress and developing new models for ...
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