Search for European Projects

33 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Zoonotic Anticipation and Preparedness Initiative (ZAPI)

Start date: Mar 1, 2015, End date: Feb 29, 2020,

Emerging infectious diseases are occurring at increasing frequency in Europe and other regions of the world, having profound impacts on public and/or veterinary health as well as disruptive effects on sector, regional or even global economy. The predominantly zoonotic nature of emerging pathogens calls for a One Health approach uniting the human medical and veterinary fields, dedicated to swiftly ...
Read Project

 21

 FINISHED 

Activation and Regulation of the NLRP3 Inflammasome (InflammAct)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

The innate immune system protects the host from infections, detects and repairs tissue damage and functions to maintain tissue homeostasis. Several families of signaling receptors can recognize microbial substances or altered host molecules and orchestrate a coordinated inflammatory response. Inflammasomes are signaling platforms that control proteolytic activation of highly proinflammatory cytoki ...
Read Project

 1

 FINISHED 

Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
Read Project

 27

 FINISHED 

The other side of optogenetics: multicolored genetically encoded hybrid voltage sensors (GEVOS) for ultrafast membrane potential measurements in cortical microcircuits (MULTIGEVOS)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Optogenetics are used to activate or silence specific sets of neurons, intracellular signaling pathways, or to examine brain structure at an unprecedented detail. The only optogenetic approach lagging behind all others is the genetically encoded optical monitoring of multi-neuronal activity at a time resolution of single action potentials. Such ultrafast (
Read Project

 1

 FINISHED 

Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system (NEUROPAIN)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous inv ...
Read Project

 12

 FINISHED 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
Read Project

 20

 FINISHED 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
Read Project

 19

 FINISHED 

Consortium on Organ Preservation in Europe (COPE)

Start date: Jan 1, 2013, End date: Jun 30, 2018,

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive inj ...
Read Project

 16

 FINISHED 

European stem cell consortium for neural cell replacement, reprogramming and functional brain repair (Neurostemcellrepair)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Neurostemcellrepair aims at taking human stem cells through the final steps toward clinical application in cell replacement therapy for neurological disorders. PD will be taken as the prototypical disease because stem cell therapy is now close to clinical translation. Moreover, we will tackle next generation issues pertaining to stem cells at a basic level and develop new approaches and novel cell ...
Read Project

 13

 FINISHED 

Open Project for the European Radiation Research Area (OPERRA)

Start date: Jun 1, 2013, End date: May 31, 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
Read Project

 71

 FINISHED 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
Read Project

 32

 FINISHED 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
Read Project

 39

 FINISHED 

Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
Read Project

 29

 FINISHED 

European Bank for induced pluripotent Stem Cells (EBISC)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
Read Project

 30

 FINISHED 

Patient-centered palliative care pathways in advanced cancer and chronic disease (INSUP-C)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

Integrated delivery systems of care, e.g. networks of health organizations and professionals who work together to coordinate services to meet their patients’ needs, are an important way of linking fragmented services and maximizing system efficiency and seamlessness of patient transition. Research increasingly shows that patients with advanced cancer and advanced chronic disease are treated well ...
Read Project

 11

 FINISHED 

Quantitative Large Scale Proteomics of Lysosomal Storage Disease (Storage Proteomics)

Start date: Aug 1, 2012, End date: Jul 31, 2016,

Lysosomal storage diseases (LSD) are a group of ~ 50 genetic disorders, which mainly affect children. LSDs are clinically heterogeneous but are frequently dominated by progressive neurologic deterioration. Most patients pass away after years of lingering illness. In general, the molecular pathogenesis of LSDs is still poorly understood. To gain insight into disease mechanisms the project investiga ...
Read Project

 1

 FINISHED 

Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure (Panacreas)

Start date: Mar 1, 2011, End date: Feb 29, 2016,

Pancreatic ductal adenocarcinoma (PDAC) causes 34000 deaths in the EU every year. Conventional cancer treatments have close to no impact on this disease. As a result, almost all patients diagnosed with PDAC develop metastases and eventually die. Given this poor outlook, the search for new therapeutics is mandatory. These will have to target relevant cancer pathways and be designed based on the ava ...
Read Project

 12

 FINISHED 

European Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS (EuroCoord)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

Over the past 15 years, EU-funded cohorts and collaborations (EuroSIDA, CASCADE and PENTA), have played a central role in developing our understanding of HIV progression and the effects of ART, enabling European expertise to contribute directly to the advances in patient diagnosis and management worldwide, and providing a continued surveillance mechanism for detection of emerging problems at a Eur ...
Read Project

 26

 FINISHED 

Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely ...
Read Project

 16

 FINISHED 

Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serio ...
Read Project

 15

 FINISHED 

Infectious triggers of chronic autoimmunity (INTRICATE)

Start date: Nov 1, 2010, End date: Apr 30, 2015,

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the ...
Read Project

 13

 FINISHED 

Helminth-induced regulatory mechanisms that prevent the onset of diabetes (HELMINTH & DIABETES)

Start date: Apr 1, 2011, End date: Mar 31, 2015,

In Europe >33 million people suffer from diabetes, a chronic disease associated with long-term pathology representing one of the biggest cost factors for the health care system. The ultimate goal of this proposal is to develop a novel immunomodulatory diabetes therapy by identifying parasitic worm (helminth) regulatory mechanisms which protect against autoimmune diseases. The applicants’ previous ...
Read Project

 1

 FINISHED 

IMplementation of quality indicators in PAlliative Care sTudy (IMPACT)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

"New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies ar ...
Read Project

 14

 FINISHED 

"CATO - CBRN crisis management: Architecture, Technologies and Operational Procedures" (CATO)

Start date: Jan 1, 2012, End date: Dec 31, 2014,

"CATO proposes to develop a comprehensive Open Toolbox for dealing with CBRN crises due to terrorist attacks using non-conventional weapons or on facilities with CBRN material. CATO will:• combine CBRN knowledge, planning & response know-how, DSS building blocks and dedicated models and algorithms• enable the development of specific holistic CBRN-DSS• cover the entire CBRN disaster life cycle from ...
Read Project

 28

 FINISHED 

Disaster Training Curriculum (DITAC)

Start date: Jan 1, 2012, End date: Dec 31, 2014,

The EU aims to consolidate and enhance its disaster response capacity by creating a European Emergency Response Center. This institution should be complimented by a standardised European training curriculum for professional crisis response.A European multi-disciplinary team of experts is collaborating to develop a standardised curriculum for international crises management hereby referred to as DI ...
Read Project

 13

 FINISHED 

Access to Opioid Medication in Europe (ATOME)

Start date: Dec 1, 2009, End date: Nov 30, 2014,

"Medicines derived from opium are very valuable in medicine practice & therefore regarded as essential medicines. However, they are generally not readily available for patients who are in need of them for medical reasons. It is estimated that over 80% of the world's population is inadequately treated, because opioid (pain relieving) medicines have been categorized as ""controlled substances"", du ...
Read Project

 11

 FINISHED 

Integration of Chikungunya research (ICRES)

Start date: Dec 1, 2010, End date: Nov 30, 2014,

Since 2005 Chikungunya fever has affected millions of people producing a high fever and a debilitating arthralgia which can persist for months and progress to chronic arthritis. Chikungunya virus has been associated with periodic outbreaks of human disease and is spread by mosquitoes. The current epidemic rose to prominence in 2005/6 following infection of >250,000 people on La Réunion. The virus ...
Read Project

 15

 FINISHED 

Cytosolic recognition of foreign nucleic acids: Molecular and functional characterization of AIM2, a central player in DNA-triggered inflammasome activation (AIM2 INFLAMMASOME)

Start date: Dec 1, 2009, End date: Nov 30, 2014,

Host cytokines, chemokines and type I IFNs are critical effectors of the innate immune response to viral and bacterial pathogens. Several classes of germ-line encoded pattern recognition receptors have been identified, which sense non-self nucleic acids and trigger these responses. Recently NLRP-3, a member of the NOD-like receptor (NLR) family, has been shown to sense endogenous danger signals, e ...
Read Project

 1

 FINISHED 

Paving the Way for Future Emerging DNA-based Technologies: Computer-Aided Design and Manufacturing of DNA libraries (CADMAD)

Start date: Feb 1, 2011, End date: Oct 31, 2014,

CADMAD aims to make a foundational breakthrough in the way computers and computer-aided design and manufacturing is employed in DNA-based research and development, making a radically new use of information technologies in biology and biotechnology.Biology and biotechnology research involves "DNA programming", which is akin to computer programming. Researchers modify and combine DNA of interest in ...
Read Project

 12

 FINISHED 

Enhanced Protective Immunity Against Filariasis (E PIAF)

Start date: Mar 1, 2010, End date: Aug 31, 2014,

"Filarial infections remain a major public health problem in West and Central Africa. Three filarial species are involved: Onchocerca volvulus (onchocerciasis or river blindness); Wuchereria bancrofti (lymphatic filariasis); and Loa loa (the eye worm). Treatment of onchocerciasis with ivermectin has been successful in many situations but emergence of drug resistance and risk of severe adverse reac ...
Read Project

 11

 FINISHED 

European Research Ethics Committees’ Network (EURECNET)

Start date: Mar 1, 2011, End date: Aug 31, 2014,

EURECNET is a network that brings together national REC associations, networks or comparable initiatives but also other bodies relevant in the field of research involving human participants like National Ethics Councils and the European Commission’s ethical review system. Such a network forms the infrastructural basis to promote awareness of specific working practices of RECs across Europe, to enh ...
Read Project

 22

 FINISHED 

Investigation of Beta-Amyloid Peptide Effects On Mitochondria Protein Homeostasis: From Pathogenesis to Therapy of Alzheimer Disease (MITOABETA)

Start date: May 1, 2012, End date: Apr 30, 2014,

"Beta-amyloid peptide, a component of senile plaques and generated by proteolytic cleavage of the amyloid precursor protein (APP), is a key factor in the pathogenesis of Alzheimer disease (AD). Beta-amyloid peptide has been shown to influence negatively some important mitochondrial activities such as reducing the efficiency of ATP-production via oxidative phosphorylation, enhancing mitochondrial R ...
Read Project

 1

 FINISHED 

Genomic variations underlying common behavior diseases and cognition trait in human populations (ADAMS)

Start date: Oct 1, 2009, End date: Sep 30, 2012,

"The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer's disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated wi ...
Read Project

 12