Search for European Projects

4 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Molecular basis of the recognition of foreign nucleic acids in innate immunity (Nucleic Acids Sensor)

Start date: Dec 1, 2008, End date: Nov 30, 2012,

The innate immunity system for vertebrates represents the front-end of their defense against invading viruses and bacteria. Its activation is based on the recognition of pathogen associated molecular patterns (PAMPs) by specialized receptors. Central in the pathogen recognition process is the detection of nucleic acids. However, how exactly foreign nucleic acids are distinguished from host DNA and ...
Read Project

 1

 FINISHED 

AID in adaptive immunity and beyond (AID and beyond)

Start date: Dec 1, 2008, End date: Nov 30, 2012,

This proposal revolves around the enzyme Activation-Induced Deaminase (AID). AID plays a pivotal role in adaptive immunity because it is essential to introduce the lesions in the immunoglobulin genes that ultimately lead to somatic hypermutation (SHM), class switch recombination (CSR) and immunoglobulin gene conversion (Ig GC). However, its mutagenic ability has a pernicious side effect and AID ha ...
Read Project

 1

 FINISHED 

Determining the Epigenetic Mechanism of Centromere Propagation (Epicentromere)

Start date: Apr 1, 2008, End date: Mar 31, 2012,

The centromere is a unique specialized chromatin domain responsible for the nucleation of the kinetochore, a large proteinaceous complex that, during mitosis, powers and controls chromosome movement on spindle microtubules ensuring accurate chromosome segregation, thereby preventing aneuploidy, a major hallmark of human cancers. Although directly embedded in chromatin no specific DNA sequence is e ...
Read Project

 1

 FINISHED 

Energy signaling in the stress response (ESIS)

Start date: Dec 1, 2008, End date: Nov 30, 2011,

"Plants are constantly confronted by multiple types of nutritional, abiotic and biotic stress. Often associated with stress is a reduction in photosynthesis and/or respiration, which in turn results in energy deprivation and ultimately in growth arrest. Despite their distinct origin and mode of perception, different stresses trigger similar downstream responses that include largely overlapping pat ...
Read Project

 1