Search for European Projects

15 European Projects Found

Searched on 125080 European Projects

 FINISHED 

QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy (QUIC-CONCEPT)

Start date: Sep 1, 2011, End date: Dec 31, 2017,

The QuIC-ConCePT consortium has 2 objectives: 1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision- ...
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 26

 FINISHED 

Academia and Industry Collaboration for Digital Pathology (AIDPATH)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

"Advances in digital pathology are generating huge volumes of whole slide and tissue microarray images which are providing new insights into the causes of some of today’s most devastating diseases. They also present tremendous opportunities for developing and evaluating new and more effective treatments that may revolutionize the care of patients with cancers and other diseases. The challenge is t ...
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 11

 FINISHED 

Recognising Adverse Drug Reactions (WEB-RADR)

Start date: Sep 1, 2014, End date: Aug 31, 2017,

WEB-RADR is a consortium of leading experts in pharmacovigilance from regulatory agencies, research, academia and patient support groups. Together with EFPIA partners our aims will be to set policy & guidance and deliver robust information technology tools to address the potential for the reporting of adverse drug reactions (ADRs) through mobile applications and the recognition of drug safety sign ...
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 20

 FINISHED 

Coordinating Action Systems Medicine – Implementation of Systems Medicine across Europe (CASYM)

Start date: Nov 1, 2012, End date: Apr 30, 2017,

The aim of CASyM is a combined large scale effort to sustainably implement Systems Medicine across Europe. For that purpose CASyM will function as a managing and coordinating platform in bringing together a critical mass of relevant European stakeholders such as Systems Biology scientists, clinicians, programme managers, industry/SMEs as well as healthcare providers and patient organizations. The ...
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 24

 FINISHED 

European Bank for induced pluripotent Stem Cells (EBISC)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

 FINISHED 

The development of in silico process models for roll compaction (IPROCOM)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

"Particulate materials, e.g. pharmaceutical formulations, precious metal, fine chemical, metal & ceramic powders, have been compacted to produce a wide range of particulate products in a number of industrial sectors. The diversity of particulate materials and the complexity of manufacturing processes make it a challenging task in product development and process design for particulate product manuf ...
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 10

 FINISHED 

Beta-cell function in juvenile diabetes and obesity (Beta-JUDO)

Start date: Feb 1, 2012, End date: Nov 30, 2016,

The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we pr ...
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 12

 FINISHED 

Network for Integrated Cellular Homeostasis (NICHE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"There is a need for greater understanding of integrated cellular physiology to exploit cells and to tailor their activities to optimise microbial productivity in synthetic circuits and to limit microbial activity in food and pharmaceutical products. Understanding the integration of the cellular metabolic processes is fundamental to developing and exploiting cells. We have assembled a team of inte ...
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 9

 FINISHED 

Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED)

Start date: Oct 1, 2009, End date: Sep 30, 2015,

RationaleThe inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.HypothesisThe use of biomarker profiles comprised of various types of hi ...
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 42

 FINISHED 

The Body-on-a-Chip (BoC) (BOC)

Start date: Jun 1, 2012, End date: May 31, 2015,

High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. T ...
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 5

 FINISHED 

The DNA damage response and breast cancer (DDRESPONSE)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in ...
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 6

 FINISHED 

The role of the Calcium Sensing Receptor (CaSR) in health and disease, implications for translational medicine (MULTIFACETED CASR)

Start date: Jan 1, 2011, End date: Dec 31, 2014,

The identification of the extracellular calcium sensing receptor (CaSR) was a crucial step in understanding nutrient sensing in mammals. In mammalian organisms the CaSR has multiple roles: besides calcium homeostasis, it is involved in protection against osteoporosis, blood vessel calcification, prevention against colorectal cancer, is involved in metastasis of breast and prostate cancer cells to ...
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 9

 FINISHED 

Innovative Synthesis in Continuous-Flow Processes for Sustainable Chemical Production (SYNFLOW)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

The SYNFLOW vision is the paradigm shift from batch-wise large volume processes in pharmaceuticals, fine chemicals and intermediates production comprising many separate unit operations towards highly integrated but yet flexible catalytic continuous flow processing. For this purpose, SYNFLOW develops a unique integrative approach combining molecular understanding of synthesis and catalysis with eng ...
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 23

 FINISHED 

Translational Science for Vascular Inflammation and Remodelling (TranSVIR)

Start date: Dec 1, 2009, End date: Nov 30, 2013,

The rapid advance of biology is providing new insights into the causes of some of today’s most pressing medical problems as well as huge opportunities to develop and evaluate novel and more effective treatments. The challenge is to exploit these advances effectively and this will require a new breed of translational scientist with expertise in a specific discipline coupled with a broad understandi ...
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 6

 FINISHED 

Flexible, Fast and Future Production Processes (F³ FACTORY)

Start date: Jun 1, 2009, End date: Jul 31, 2013,

The F3 consortium’s vision is that the EU’s chemical industry’s competitive position would be strongly enhanced if it could operate modular continuous plant (F3 plant) which combines world scale continuous plant efficiency, consistency and scalability with the versatility of batch operation. Our project will deliver such a radically new production mode based on: a) Plug–and–play modular chemical ...
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 29