‘Organ-on-Chip’ (OoC) is a promising technology for achieving more effective in-vitro research in a broad range of life science sectors, including medicine and pharmacy, cosmetics, agriculture and food, and for chemical safety testing including regulatory testing. More effective drug development, efficacy and safety screening, would reduce the need for animal testing and clinical testing. Nevertheless, much more research and development is needed to develop more robust, automated and parallelised OoC technologies that are applicable in industry, with medium to high throughput capacity, reliability and repeatability, using validated and standardised tools and methods.
Scope:A related topic (SC1-BHC-11-2020: Advancing the safety assessment of chemicals without the use of animal testing) is published under the part "Health, demographic change and wellbeing" of the work Programme.[1]
Proposals submitted under this topic should include a business case and exploitation strategy, as outlined in the Introduction to the LEIT part of this Work Programme.
Activities should start at TRL 3 and achieve TRL 5 at the end of the project.
Please note that this topic will take the form of lump sums as defined in Commission Decision C(2017)7151 of 27 October 2017[2]. Details of the lump sum funding pilot scheme are published on the Funding & Tenders Portal[3] together with the specific Model Grant Agreement for Lump Sums[4] applicable.
The Commission considers that proposals requesting a contribution from the EU of between EUR 4 and 6 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.
Expected Impact:[1]http://ec.europa.eu/research/participants/data/ref/h2020/wp/2018-2020/main/h2020-wp1820-health_en.pdf
[2]http://ec.europa.eu/research/participants/data/ref/h2020/other/legal/lump_sum/lumpsumdecision-2017-7151_en.pdf
[3]http://ec.europa.eu/research/participants/docs/h2020-funding-guide/grants/applying-for-funding/find-a-call/what-you-need-to-know_en.htm
[4]http://ec.europa.eu/research/participants/data/ref/h2020/mga/lumpsum/h2020-mga-lumpsum-pilot-multi_en.pdf
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